Trifarotene
Fourth-generation retinoid with selective action on RAR-gamma receptors. Galderma markets it as Aklief for facial and truncal acne.
AcneAnti-aging
Evidence by route
Topical application
AProven efficacy. Two or more independent RCTs with instrumental endpoints.
FDA approved trifarotene in 2019 as the first retinoid with proven efficacy for truncal acne. The selectivity reduces irritation compared with tretinoin.
Tolerability and safety
Irritation potential
MediumAllergen risk
LowPregnancy
AvoidSkin types
Use with caution
Sensitive
Frequently asked questions
Is Trifarotene safe during pregnancy?
Trifarotene is not recommended during pregnancy. Consider an alternative from the same category.
What skin types is Trifarotene for?
Use with caution in: sensitive.
Can Trifarotene irritate the skin?
Trifarotene has moderate irritation potential. Sensitive skin may show a transient reaction that usually settles with adaptation.