Urea

A natural moisturizing factor (NMF) present in the stratum corneum. Low concentrations moisturize; high concentrations act as a keratolytic. The gold standard for hyperkeratosis and xerosis.

MoisturizingBarrier repair

Evidence by route

Topical application

Proven efficacy. Two or more independent RCTs with instrumental endpoints.

Dozens of RCTs and dermatological society guidelines confirm efficacy for xerosis, atopic dermatitis, and hyperkeratosis. Reduces TEWL, restores NMF, and enhances penetration of other active ingredients.

Pan M et al. Int J Pharm. 2013;447(1-2):4-11.
Pham QD et al. Mol Pharm. 2016;13(11):3685-3692.

Working concentrations

2–10% for hydration; 20–40% for keratolytic effect

Tolerability and safety

Irritation potential

Low

Allergen risk

Low

Pregnancy

Safe

For sensitive skin

At concentrations above 10%, it may sting on damaged or inflamed skin. Start at 5%.

Skin types

Suitable for

DryNormalSensitiveCombination

Frequently asked questions

Is Urea safe during pregnancy?

Urea is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.

What skin types is Urea for?

Urea suits: dry, normal, sensitive, combination.