Moderate
Alprazolam × Furosemide
Benzodiazepines. Short-to-medium-acting anxiolytics×Loop diuretics
Mechanism
Additive hypotension and fall risk in older patients. No direct pharmacokinetic interaction.
Symptoms
Lower blood pressure, postural dizziness, fatigue. Older patients: fall risk.
Management
In older patients, check standing and sitting blood pressure 1–2 weeks after starting alprazolam. Alternative anxiolytic: hydroxyzine or a short lorazepam course.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.