Minor
Amlodipine × Ciprofloxacin
Calcium channel blockers (dihydropyridines)×Fluoroquinolone antibacterials
Mechanism
No clinically significant direct interaction. Ciprofloxacin weakly inhibits CYP3A4, which partly metabolises amlodipine. Amlodipine levels may rise slightly.
Symptoms
The combination usually causes no specific symptoms. Each drug's individual side effects remain.
Management
For short ciprofloxacin courses (5–7 days), no adjustment needed. In older patients, watch for leg oedema and dizziness in the first week.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.