ModerateCalcium channel blockers (dihydropyridines)×NSAID, COX-2 preferential, oxicam derivative
Updated · Methodology
Mechanism
NSAIDs antagonise amlodipine's antihypertensive effect via renal prostaglandin-dependent sodium regulation suppression.
Symptoms
Gradual blood pressure rise 1–2 weeks after starting meloxicam. In chronic kidney disease: fluid retention and oedema risk.
Management
For short meloxicam courses (5–7 days), monitor blood pressure. For chronic analgesia: switch to paracetamol or celecoxib (with PPI cover).
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
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Sources
- FDA: Meloxicam tablet (Terrain Pharmaceuticals, Inc.) – Prescribing Information (2012)– ; DailyMed setid b603255e-1fcf-42ec-ab62-9aa321cb7ac6