ModerateCalcium channel blockers (dihydropyridines)×Systemic glucocorticoid
Updated · Methodology
Mechanism
Similar to amlodipine + prednisolone. Methylprednisolone causes sodium retention via mineralocorticoid effect, reducing amlodipine's antihypertensive action.
Symptoms
Gradual blood pressure rise 2–4 weeks after starting the glucocorticoid. In heart failure: oedema, weight gain.
Management
For short methylprednisolone courses, no adjustment. For prolonged systemic therapy, increase amlodipine or add a diuretic (hydrochlorothiazide, indapamide) with blood pressure monitoring every 2 weeks.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
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Sources
- FDA: Norvasc (amlodipine) prescribing information (2017)– ; DailyMed setid 7367289c-b0b0-466a-83e2-558e2985c29f