MinorHerbal anti-inflammatory agents×Anilides. Analgesics and antipyretics
Updated · Methodology
Mechanism
Curcumin (Curcuma longa extract) theoretically weakly inhibits CYP2E1, which produces paracetamol's hepatotoxic metabolite NAPQI. For short paracetamol courses, hepatotoxicity risk may be slightly reduced. Clinical data are limited.
Symptoms
The combination usually causes no specific symptoms. Each drug's individual side effects remain.
Management
No dose adjustment needed. Dietary curcumin (curry, golden milk) does not clinically affect paracetamol metabolism. At supplement doses of curcumin (500–1000 mg/day), no clinically significant interaction has been documented. Paracetamol limit: up to 3 g/day.
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Sources
- FDA: Tylenol 8 HR Arthritis Pain (acetaminophen) – label (2020)– ; DailyMed setid 3af22fc8-e4e0-4863-8696-6bc1257047cb