MinorNon-steroidal anti-inflammatory drugs, propionic acid derivatives×Anilides. Analgesics and antipyretics
Updated · Methodology
Mechanism
Dexketoprofen is an NSAID and paracetamol is not, so the label restriction on combining several NSAIDs does not apply here. The mechanisms differ: peripheral cyclooxygenase inhibition versus central action, which is why the pair is used in moderate acute pain. Neither drug alters the metabolism of the other.
Symptoms
No symptoms specific to the pair. Dexketoprofen brings the gastrointestinal and renal risk of any NSAID: epigastric pain, nausea, black stools, oedema or reduced urine output. Paracetamol brings hepatic risk once the 4 g daily limit is passed.
Management
They can be combined or alternated in acute pain. Dexketoprofen is used in short courses at the lowest effective dose and is not stacked with another NSAID. Paracetamol is counted separately, up to 4 g a day.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
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Sources
- AEMPS: Ficha técnica Paracetamol Abamed 1 g comprimidos EFG (2020)– AEMPS, CIMA, nº registro 77758, secciones 4.2 y 4.5
- AEMPS: Ficha técnica Dexketoprofeno Cinfa 25 mg comprimidos recubiertos con película EFG (2025)– AEMPS, CIMA, nº registro 77839, sección 4.5