MajorNon-steroidal anti-inflammatory drugs (NSAIDs)×Psycholeptics. Lithium
Updated · Methodology
Mechanism
Similar to naproxen + lithium. NSAIDs reduce renal lithium clearance via prostaglandin blockade.
Symptoms
Tremor, muscle twitching, nausea, diarrhoea, confusion, ataxia. Symptoms emerge when serum lithium exceeds 1.2 mmol/L.
Management
Avoid prolonged combination. If diclofenac is needed for a short course, reduce lithium by 25–30% and check level at 5–7 days. For chronic analgesia: paracetamol.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Lithium prescribing information section 7 (2016)– ; DailyMed setid b839ff4b-f62d-41ab-a823-550a756d58ec
- AEMPS: Ficha técnica: Litio (nº registro 48932), sección 4.5 (2025)– AEMPS, CIMA, nº registro 48932, revisión 04/2025, sección 4.5