Critical
Rifampicin × Rivaroxaban
Antituberculous antibiotic×Direct oral anticoagulants (factor Xa inhibitors)
Mechanism
Rifampicin is a strong CYP3A4 + P-gp inducer. Rivaroxaban falls 50% – anticoagulation lost.
Symptoms
Stroke or recurrent VTE.
Management
Combination contraindicated. Alternative – warfarin to target INR.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.