MajorAntituberculous antibiotic×Selective immunosuppressant, mTOR inhibitor
Updated · Methodology
Mechanism
Strong CYP3A4 + P-gp inducer. Sirolimus falls 70% – rejection risk.
Symptoms
Rejection signs.
Management
Alternative TB regimen. If rifampicin necessary – triple sirolimus dose.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Rapamune (sirolimus) prescribing information (2017)
- EMA: Ficha técnica: Sirolimús (EU/1/01/171), sección 4.5 (2026)– EMA SmPC vía AEMPS CIMA, nº 01171013 (EU/1/01/171), sección 4.5, consultado 10/2026