A synthetic peptide marketed for muscle-relaxing effect. The maker links it to smoothing expression lines; independent data are limited.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A peptide active. Well tolerated; independent data limited.
Dipeptide diaminobutyroyl benzylamide diacetate (INCI: Dipeptide Diaminobutyroyl Benzylamide Diacetate) is a synthetic peptide used in anti-aging cosmetics, marketed as an argireline-like ingredient. The supplier links it to a surface muscle-relaxing effect that should soften expression lines. Honesty is needed here: the idea of mimicking the botulinum toxin mechanism comes mostly from the supplier, and independent evidence is thin. Applied in a cream, the peptide does not reach the muscle the way an injection does. It is a supporting active with a subtle effect, not a botox substitute. Topically it is not systemically relevant, so it can be used during pregnancy and breastfeeding without concern. Tolerance is high, with low irritation and allergy potential, suitable for sensitive skin.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Dipeptide Diaminobutyroyl Benzylamide Diacetate is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Dipeptide Diaminobutyroyl Benzylamide Diacetate suits: normal, dry, combination, oily, sensitive.
A synthetic peptide marketed for muscle-relaxing effect.
The INCI name is Dipeptide Diaminobutyroyl Benzylamide Diacetate. It may also appear as: Syn-Ake, Diaminobutyroyl Hydroxythreonine.
Published: · updated: