Glycosphingolipids
Sphingolipid family of the stratum corneum; barrier component. Functional formulation ingredient with no standalone activity on the skin.
Evidence by route
Topical application
Inert formulation ingredient. Safe, no standalone activity.
How to read tiers A–F
- CWeak evidence. In vitro data, open-label studies, or expert consensus
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
About this ingredient
Glycosphingolipids are a class of sphingolipids with a carbohydrate residue, a barrier component of the stratum corneum. They form part of keratinocyte lamellar bodies alongside ceramides and cholesterol – building the hydrophobic "cement" of the epidermal barrier. Where applied. Repair creams and serums for atopic and dry skin, barrier-positioned products. Often combined with ceramides and phytosphingosine – in La Roche-Posay Toleriane Sensitive, CeraVe, Bioderma Atoderm. Evidence base. Sphingolipids as a class have been studied in atopic dermatitis, psoriasis, eczema – fraction deficiency speeds up TEWL and worsens inflammation (Imokawa 1991). Direct RCTs of glycosphingolipids specifically are few; data come from ceramide-enriched formulas. Safety. CIR confirmed safety. Hypoallergenic, non-comedogenic. Pregnancy and lactation – safe.
Frequently asked questions
Is Glycosphingolipids safe during pregnancy?
Glycosphingolipids is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What is Glycosphingolipids and what does it do in cosmetics?
Sphingolipid family of the stratum corneum; barrier component.
What's the INCI name for Glycosphingolipids?
The INCI name is Glycosphingolipids.
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The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
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