Synthetic modified dipeptide with a claimed anti-aging effect. Evidence base is limited to manufacturer-sponsored studies.
Topical application
DVery weak or conflicting data.
Patented peptide with marketing claims about barrier strengthening and anti-aging. Independent topical studies are essentially absent.
Heptasodium Hexacarboxymethyl Dipeptide-12 is a synthetic modified dipeptide with six carboxymethyl groups and sodium counterions. One of the modern "biomimetic" peptides with claimed anti-aging effect. Mechanism. The manufacturer (Lipotec, Lubrizol) describes the molecule as a modulator of collagen and elastin synthesis in fibroblasts. The direct receptor binding mechanism is not specified. Where applied. Anti-aging serums and creams (1-5% commercial complex). Common in the premium segment. Evidence base. Limited to manufacturer-sponsored studies (Lipotec): 12-week clinical trials in 20-30 women – improved skin firmness. No independent RCTs; data not reproduced in peer-reviewed journals. Safety. CIR has not made a separate assessment. Contact reactions are rare at standard cosmetic concentrations. Pregnancy – use with caution (UNKNOWN). Lactation – safe per manufacturer, but no direct data.
Irritation potential
LowAllergen risk
LowPregnancy
CautionSuitable for
Use with caution
The Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Heptasodium Hexacarboxymethyl Dipeptide-12 should be used with caution during pregnancy. Consulting a dermatologist or OB-GYN is advisable.
Heptasodium Hexacarboxymethyl Dipeptide-12 suits: normal, dry, oily, combination. Use with caution in: sensitive.
Synthetic modified dipeptide with a claimed anti-aging effect.
The INCI name is Heptasodium Hexacarboxymethyl Dipeptide-12. It may also appear as: Hexacarboxymethyl Dipeptide-12.
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