Heptasodium Hexacarboxymethyl Dipeptide-12
Synthetic modified dipeptide with a claimed anti-aging effect. Evidence base is limited to manufacturer-sponsored studies.
Evidence by route
Topical application
Patented peptide with marketing claims about barrier strengthening and anti-aging. Independent topical studies are essentially absent.
How to read tiers A–F
- DNo data, or very weak or conflicting data
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Caution
- Suitable for
- Normal, Dry, Oily, Combination
- Use with caution
- Sensitive
About this ingredient
Heptasodium Hexacarboxymethyl Dipeptide-12 is a synthetic modified dipeptide with six carboxymethyl groups and sodium counterions. One of the modern "biomimetic" peptides with claimed anti-aging effect. Mechanism. The manufacturer (Lipotec, Lubrizol) describes the molecule as a modulator of collagen and elastin synthesis in fibroblasts. The direct receptor binding mechanism is not specified. Where applied. Anti-aging serums and creams (1-5% commercial complex). Common in the premium segment. Evidence base. Limited to manufacturer-sponsored studies (Lipotec): 12-week clinical trials in 20-30 women – improved skin firmness. No independent RCTs; data not reproduced in peer-reviewed journals. Safety. CIR has not made a separate assessment. Contact reactions are rare at standard cosmetic concentrations. Pregnancy – use with caution (UNKNOWN). Lactation – safe per manufacturer, but no direct data.
Frequently asked questions
Is Heptasodium Hexacarboxymethyl Dipeptide-12 safe during pregnancy?
Heptasodium Hexacarboxymethyl Dipeptide-12 should be used with caution during pregnancy. Consulting a dermatologist or OB-GYN is advisable.
What skin types is Heptasodium Hexacarboxymethyl Dipeptide-12 for?
Heptasodium Hexacarboxymethyl Dipeptide-12 suits: normal, dry, oily, combination. Use with caution in: sensitive.
What is Heptasodium Hexacarboxymethyl Dipeptide-12 and what does it do in cosmetics?
Synthetic modified dipeptide with a claimed anti-aging effect.
What's the INCI name for Heptasodium Hexacarboxymethyl Dipeptide-12?
The INCI name is Heptasodium Hexacarboxymethyl Dipeptide-12. It may also appear as: Hexacarboxymethyl Dipeptide-12.
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