Hesperidin Methyl Chalcone
A citrus flavonoid derived from hesperidin. In cosmetics it is used as a vascular-supporting ingredient in anti-redness and anti-age eye products. The manufacturer claims reduced capillary permeability and lessened dark circles and puffiness. Found in well-known eye complexes (Eyeliss, Haloxyl).
Evidence by route
Topical application
Clinical studies within peptide-flavonoid complexes (Eyeliss, Haloxyl) showed reduction in dark circles by instrumental measurements. No independent head-to-head comparisons with other approaches (caffeine, vitamin K, pigment correctors).
- Sederma. Eyeliss technical documentation. 2012.
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Combination, Sensitive
About this ingredient
Hesperidin Methyl Chalcone (HMC) is a modified flavonoid from citrus, the methylated chalcone derivative of hesperidin. Used in cosmetics as a vascular-supporting ingredient. Mechanism. Reduces capillary permeability via hyaluronidase and elastase inhibition. Reduces plasma and pigment molecule extravasation from periorbital capillaries – theoretically reduces dark circles and puffiness. Where applied. Eye-area creams (0.5-2%), dark-circle and couperose formulas. Included in ready-made ingredient complexes Eyeliss and Haloxyl by Sederma – marketing "actives" in premium eye creams. Evidence base. Sederma cites 28-day studies in 22 volunteers: under-eye bag reduction by 70%, dark circles by 60% with 2% HMC + dipeptide-2. Few independent peer-reviewed RCTs. Safety. CIR confirmed safety. Hypoallergenic. Pregnancy – safe topically. Lactation – no data, but topical use poses no documented systemic risk.
Frequently asked questions
Is Hesperidin Methyl Chalcone safe during pregnancy?
Hesperidin Methyl Chalcone is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Hesperidin Methyl Chalcone for?
Hesperidin Methyl Chalcone suits: normal, dry, combination, sensitive.
What is Hesperidin Methyl Chalcone and what does it do in cosmetics?
A citrus flavonoid derived from hesperidin.
What's the INCI name for Hesperidin Methyl Chalcone?
The INCI name is Hesperidin Methyl Chalcone. It may also appear as: HMC.
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