Hesperidin Methyl Chalcone
A citrus flavonoid derived from hesperidin. In cosmetics it is used as a vascular-supporting ingredient in anti-redness and anti-age eye products. The manufacturer claims reduced capillary permeability and lessened dark circles and puffiness. Found in well-known eye complexes (Eyeliss, Haloxyl).
Evidence by route
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Clinical studies within peptide-flavonoid complexes (Eyeliss, Haloxyl) showed reduction in dark circles by instrumental measurements. No independent head-to-head comparisons with other approaches (caffeine, vitamin K, pigment correctors).
- Sederma. Eyeliss technical documentation. 2012.
Tolerability and safety
Irritation potential
LowAllergen risk
LowPregnancy
SafeSkin types
Suitable for
Frequently asked questions
Is Hesperidin Methyl Chalcone safe during pregnancy?
Hesperidin Methyl Chalcone is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Hesperidin Methyl Chalcone for?
Hesperidin Methyl Chalcone suits: normal, dry, combination, sensitive.