Lipopeptide mimicking a collagen fragment. Stimulates fibroblasts to produce collagen and hyaluronic acid. Often combined with palmitoyl tetrapeptide-7 (Matrixyl 3000).
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
Small sponsor-conducted studies demonstrate wrinkle reduction with the Matrixyl 3000 combination. Independent RCTs are scarce. In vitro collagenogenesis activation is shown, but clinical translation is limited by peptide penetration concerns.
Palmitoyl Tripeptide-1 (Pal-GHK, Biopeptide CL) is a synthetic lipopeptide: the tripeptide Gly-His-Lys with palmitic acid. An analog of the natural copper peptide GHK-Cu, discovered by Loren Pickart in 1973. Mechanism. Signaling peptide – activates synthesis of type I, III, IV collagen, elastin, glycosaminoglycans in fibroblasts. Metal chelator (mildly binds copper, which enhances anti-aging effect). Antioxidant. Where applied. Anti-aging serums and creams, recovery products for damaged skin. Concentration 2–10 ppm. Often in peptide complexes with matrixyl (Matrixyl 3000 plus). In Spain in Mesoestetic, Sesderma, Skeyndor. Evidence base. Pickart studies (2018) showed collagen synthesis stimulation and accelerated wound healing. Lintner 2009 RCT (n=23) confirmed wrinkle depth reduction and texture improvement over 8 weeks at 4 ppm. Moderate evidence base. Safety. CIR confirmed safety. Hypoallergenic, non-comedogenic, does not photosensitize. Pregnancy and lactation – manufacturers advise caution. No direct pregnancy data.
Irritation potential
LowAllergen risk
LowPregnancy
UnknownSuitable for
The Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Safety data for Palmitoyl Tripeptide-1 during pregnancy is insufficient. Best avoided when in doubt.
Palmitoyl Tripeptide-1 suits: normal, dry, sensitive, combination.
Lipopeptide mimicking a collagen fragment.
The INCI name is Palmitoyl Tripeptide-1. It may also appear as: Pal-GHK, Пальмитоил трипептид-1, Matrixyl 3000.
Published: · updated: