Palmitoyl Tripeptide-1
Lipopeptide mimicking a collagen fragment. Stimulates fibroblasts to produce collagen and hyaluronic acid. Often combined with palmitoyl tetrapeptide-7 (Matrixyl 3000).
Anti-aging
Evidence by route
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Small sponsor-conducted studies demonstrate wrinkle reduction with the Matrixyl 3000 combination. Independent RCTs are scarce. In vitro collagenogenesis activation is shown, but clinical translation is limited by peptide penetration concerns.
- Robinson LR et al. Int J Cosmet Sci. 2005;27(3):155-160.
Tolerability and safety
Irritation potential
LowAllergen risk
LowPregnancy
UnknownSkin types
Suitable for
NormalDrySensitiveCombination
Frequently asked questions
Is Palmitoyl Tripeptide-1 safe during pregnancy?
Safety data for Palmitoyl Tripeptide-1 during pregnancy is insufficient. Best avoided when in doubt.
What skin types is Palmitoyl Tripeptide-1 for?
Palmitoyl Tripeptide-1 suits: normal, dry, sensitive, combination.