Phytosqualane
Plant-derived squalane analogue; light, stable emollient. Functional formulation ingredient with no standalone activity on the skin.
Evidence by route
Topical application
Inert formulation ingredient. Safe, no standalone activity.
How to read tiers A–F
- CWeak evidence. In vitro data, open-label studies, or expert consensus
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
About this ingredient
Phytosqualane (plant-origin squalane) is a plant analogue of squalane. Produced by hydrogenating squalene from olive oil, sugarcane (biotech) or amaranth. Molecule identical to animal-derived squalane (from shark liver) but without ethical concerns. Where applied. Serums, creams, cleansing oils, hair and body products (1-100%). Base emollient in The Ordinary, Biossance, Caudalie, Indeed Labs. In Spain – Sesderma, ISDIN. Mechanism. Mimics squalene – a natural component of sebum (10-12% of adult sebum). Restores the lipid barrier, reduces TEWL, gives light slip without greasiness. Safety. CIR confirmed squalane/phytosqualane safety. Hypoallergenic, non-comedogenic (Fulton 0). Very stable – does not oxidise (unlike the parent squalene), does not go rancid. Pregnancy and lactation – safe. Suitable in any product, including breast care during lactation.
Frequently asked questions
Is Phytosqualane safe during pregnancy?
Phytosqualane is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What is Phytosqualane and what does it do in cosmetics?
Plant-derived squalane analogue; light, stable emollient.
What's the INCI name for Phytosqualane?
The INCI name is Phytosqualane. It may also appear as: Squalane (plant).
See Phytosqualane in a product composition right on the store page
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
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