Tripeptide-2
Short signaling peptide; studied as a skin ACE inhibitor. Functional formulation ingredient with no standalone activity on the skin.
Evidence by route
Topical application
Inert formulation ingredient. Safe, no standalone activity.
How to read tiers A–F
- CWeak evidence. In vitro data, open-label studies, or expert consensus
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
About this ingredient
Tripeptide-2 is a synthetic short peptide studied as a skin angiotensin-converting enzyme (ACE) inhibitor. It entered cosmetics after Hipkiss-era publications about the role of the tissue renin-angiotensin system in skin ageing. Mechanism. In vitro it suppresses ACE activity in keratinocytes, theoretically reducing synthesis of angiotensin II – a mediator of fibrosis and inflammation. No direct regenerative or anti-ageing effect on skin as a single ingredient has been demonstrated. Where applied. Premium anti-ageing serums and creams, often in compound peptide cocktails. Use levels in finished formulas: 0.01-0.05%. No clear niche in the ES market. Evidence base. No independent clinical RCTs with isolated tripeptide-2 exist. All marketing claims rely on in vitro work and analogies with oral ACE inhibitors (enalapril). Safety. Non-sensitising, non-comedogenic. The molecule is large, topical systemic absorption is minimal. Pregnancy and lactation – formally safe, but without proven benefit it is better to choose niacinamide or hyaluronic acid in pregnancy. Realistic expectations. A functional component of peptide blends without strong standalone activity. Not part of first-line anti-ageing routines.
Frequently asked questions
Is Tripeptide-2 safe during pregnancy?
Tripeptide-2 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What is Tripeptide-2 and what does it do in cosmetics?
Short signaling peptide; studied as a skin ACE inhibitor.
What's the INCI name for Tripeptide-2?
The INCI name is Tripeptide-2.
See Tripeptide-2 in a product composition right on the store page
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
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Tripeptide-29, Tripeptide-3, Tripeptide-32, Ubiquinone (CoQ10), Bis-Glyceryl Ascorbate, Hydroxypinacolone Retinoate, Nicotiana Benthamiana sh-Polypeptide-76, Quercetin
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