Short signaling peptide; studied as a skin ACE inhibitor. Functional formulation ingredient with no standalone activity on the skin.
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Inert formulation ingredient. Safe, no standalone activity.
Tripeptide-2 is a synthetic short peptide studied as a skin angiotensin-converting enzyme (ACE) inhibitor. It entered cosmetics after Hipkiss-era publications about the role of the tissue renin-angiotensin system in skin ageing. Mechanism. In vitro it suppresses ACE activity in keratinocytes, theoretically reducing synthesis of angiotensin II – a mediator of fibrosis and inflammation. No direct regenerative or anti-ageing effect on skin as a single ingredient has been demonstrated. Where applied. Premium anti-ageing serums and creams, often in compound peptide cocktails. Use levels in finished formulas: 0.01-0.05%. No clear niche in the ES market. Evidence base. No independent clinical RCTs with isolated tripeptide-2 exist. All marketing claims rely on in vitro work and analogies with oral ACE inhibitors (enalapril). Safety. Non-sensitising, non-comedogenic. The molecule is large, topical systemic absorption is minimal. Pregnancy and lactation – formally safe, but without proven benefit it is better to choose niacinamide or hyaluronic acid in pregnancy. Realistic expectations. A functional component of peptide blends without strong standalone activity. Not part of first-line anti-ageing routines.
Irritation potential
LowAllergen risk
LowPregnancy
SafeThe Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Tripeptide-2 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Short signaling peptide; studied as a skin ACE inhibitor.
The INCI name is Tripeptide-2. It may also appear as: Трипептид-2.
Published: · updated: