ModerateCalcium channel blockers (dihydropyridines)×Angiotensin II receptor blockers (sartans)
Updated · Methodology
Mechanism
Synergistic blood pressure reduction – a target hypertension combination. Amlodipine dilates peripheral vessels; losartan (ARB) blocks the renin-angiotensin system.
Symptoms
Older patients may have symptomatic and orthostatic hypotension, dizziness on standing. With the first losartan dose: risk of marked blood pressure drop.
Management
Standard hypertension treatment (fixed-dose product available). Take the first losartan dose in the evening, lying down. Check blood pressure and creatinine 1–2 weeks after start.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- Lexicomp: Lexicomp Drug Interactions (2024)– Wolters Kluwer Clinical Drug Information, Inc. Lexi-Interact Online, 2024
- Pharmaceutical Press: Stockley's Drug Interactions, 12th edition (2024)– Preston CL (ed.). Stockley's Drug Interactions. 12th ed. London: Pharmaceutical Press; 2024