Retinol

Forma de la vitamina A que la piel convierte en ácido retinoico. Uno de los ingredientes tópicos más estudiados con eficacia antiedad demostrada.

Anti-aging

Evidence by route

Topical application

Proven efficacy. Two or more independent RCTs with instrumental endpoints.

Randomized controlled trials confirm increased collagen production, reduced wrinkle depth, and improved skin texture with long-term use. Evidence is weaker than tretinoin because retinol requires enzymatic conversion and is less standardized in OTC concentrations.

Kafi R et al. Arch Dermatol. 2007;143(5):606-612.
Mukherjee S et al. Clin Interv Aging. 2006;1(4):327-348.

Working concentrations

0,025–1%

How to introduce

Se empieza con 0,025–0,05% una vez a la semana y se aumenta gradualmente la frecuencia y la concentración según tolerancia. La adaptación completa lleva 4–8 semanas.

Tolerability and safety

Irritation potential

High

Allergen risk

Low

Pregnancy

Avoid

For sensitive skin

Para piel sensible se recomienda el método de «buffering»: aplicar el retinol sobre la crema hidratante y no directamente sobre la piel limpia.

Skin types

Suitable for

NormalCombinationOily

Use with caution

SensitiveDry

Combinations with other ingredients

Works well with

NiacinamideНиацинамид

Niacinamide reduces retinol's irritation potential by strengthening the barrier without sacrificing efficacy.

Panthenol (Provitamin B5)Пантенол (провитамин B5)

Panthenol softens retinol adaptation in the first weeks. Reduces redness and flaking without blocking the main effect.

CeramidesЦерамиды

Ceramides restore the barrier that retinol weakens during adaptation. A must-pair for sensitive skin.

Does not combine with

Glycolic AcidГликолевая кислота

Using both in one routine raises irritation 2-3x. Alternate: retinol at night, AHA on a different evening.

Salicylic AcidСалициловая кислота

Simultaneous use raises irritation potential. Alternate every other day or split morning/evening.

Benzoyl PeroxideБензоилпероксид

Benzoyl peroxide oxidizes retinol, inactivating it. When both are needed – use at different times: BPO in morning, retinol at night.

L-Ascorbic Acid (Vitamin C)L-Аскорбиновая кислота (витамин C)

Different optimal pH: retinoids need neutral, vitamin C needs acidic. Use at different times: C in morning, retinol at night.

Frequently asked questions

¿Es seguro Retinol durante el embarazo?

Retinol no se recomienda durante el embarazo. Mejor elegir una alternativa de la misma categoría.

¿Para qué tipos de piel sirve Retinol?

Retinol es adecuado para: normal, mixta, grasa. Usar con precaución en: sensible, seca.

¿Retinol irrita la piel?

Sí, Retinol tiene un potencial irritante alto. Empezar a bajas concentraciones, introducirlo gradualmente y usar SPF a diario.