An amino-acid derivative. The maker links it to support for skin defense against stress; independent data are limited. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
An active ingredient. Well tolerated; independent data limited.
Oxothiazolidine is an amino-acid derivative (procysteine) used in cosmetics as a supporting ingredient in soothing formulas. Its INCI is Oxothiazolidine. In a product it acts as a precursor linked to glutathione synthesis, the skin's own antioxidant molecule, which is why manufacturers tie it to protection against oxidative stress. On efficacy it pays to be honest: most data come from suppliers themselves and independent evidence is thin. The sensible view is to treat it as a supporting component within a formula, not an active with solid clinical results. It promises no wonders and does not replace better-studied antioxidants such as vitamin C. Applied topically its systemic absorption is minimal, so it can be used during pregnancy and breastfeeding with no expected risk. Tolerance is good. Both irritation and allergy potential are low, so it fits sensitive skin. There is no evidence of meaningful comedogenicity.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Oxothiazolidine is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Oxothiazolidine suits: normal, dry, combination, oily, sensitive.
An amino-acid derivative.
The INCI name is Oxothiazolidine. It may also appear as: Оксотиазолидин.
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