A synthetic peptide. The maker links it to firmness and barrier support; independent data are limited. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A synthetic peptide. Safe; independent data limited.
Cetylhydroxyproline Palmitamide (INCI identical) is a lipid peptide derivative, a molecule that combines an amino-acid-type fragment with fatty chains. In cosmetics it is used with the aim of reinforcing firmness and supporting barrier function. On efficacy, expectations should be tempered. The manufacturer links it to elasticity and barrier support, and its lipid structure fits that idea, but independent data are scarce. It works more as a supporting emollient and conditioning ingredient than as an active with a proven effect on wrinkles. Topically it has no systemic relevance, so it can be used during pregnancy and breastfeeding. Tolerance is good: low irritation and allergy potential, suitable for sensitive skin. Its lipid part makes it pleasant in creamy textures meant for dry or tight skin.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Cetylhydroxyproline Palmitamide is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Cetylhydroxyproline Palmitamide suits: normal, dry, combination, oily, sensitive.
A synthetic peptide.
The INCI name is Cetylhydroxyproline Palmitamide. It may also appear as: Цетилгидроксипролин пальмитамид, Sepilift DPHP.
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