Cetylhydroxyproline Palmitamide
A synthetic peptide. The maker links it to firmness and barrier support; independent data are limited. Well tolerated.
Evidence by route
Topical application
A synthetic peptide. Safe; independent data limited.
- CIR Cosmetic Ingredient Review safety assessment
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Combination, Oily, Sensitive
About this ingredient
Cetylhydroxyproline Palmitamide (INCI identical) is a lipid peptide derivative, a molecule that combines an amino-acid-type fragment with fatty chains. In cosmetics it is used with the aim of reinforcing firmness and supporting barrier function. On efficacy, expectations should be tempered. The manufacturer links it to elasticity and barrier support, and its lipid structure fits that idea, but independent data are scarce. It works more as a supporting emollient and conditioning ingredient than as an active with a proven effect on wrinkles. Topically it has no systemic relevance, so it can be used during pregnancy and breastfeeding. Tolerance is good: low irritation and allergy potential, suitable for sensitive skin. Its lipid part makes it pleasant in creamy textures meant for dry or tight skin.
Frequently asked questions
Is Cetylhydroxyproline Palmitamide safe during pregnancy?
Cetylhydroxyproline Palmitamide is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Cetylhydroxyproline Palmitamide for?
Cetylhydroxyproline Palmitamide suits: normal, dry, combination, oily, sensitive.
What is Cetylhydroxyproline Palmitamide and what does it do in cosmetics?
A synthetic peptide.
What's the INCI name for Cetylhydroxyproline Palmitamide?
The INCI name is Cetylhydroxyproline Palmitamide. It may also appear as: Sepilift DPHP.
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