A synthetic peptide. The maker links it to smoothing and firmness; independent data are limited. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A synthetic peptide. Safe; independent data limited.
Pentapeptide-18 (INCI identical) is a synthetic five-amino-acid peptide, also known by its trade name. It is added to anti-ageing products with the idea of relaxing the muscle contraction tied to expression lines. Efficacy calls for caution. The manufacturer links it to smoothing and firmness, and there is some theoretical basis for its action on neuromuscular signalling, but independent data are scarce and small in scale. It is a support ingredient within an anti-ageing formula, without the solid backing of actives like retinoids or vitamin C. Do not expect injectable-neuromodulator-level results. Topically it has no systemic relevance, so it can be used during pregnancy and breastfeeding. Tolerance is good: low irritation and allergy potential, suitable for sensitive skin. It is one of the most comfortable peptide actives to add to a routine.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Pentapeptide-18 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Pentapeptide-18 suits: normal, dry, combination, oily, sensitive.
A synthetic peptide.
The INCI name is Pentapeptide-18. It may also appear as: Пентапептид-18, Leuphasyl.
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