Pentapeptide-18
A synthetic peptide. The maker links it to smoothing and firmness; independent data are limited. Well tolerated.
Evidence by route
Topical application
A synthetic peptide. Safe; independent data limited.
- CIR Cosmetic Ingredient Review safety assessment
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Combination, Oily, Sensitive
About this ingredient
Pentapeptide-18 (INCI identical) is a synthetic five-amino-acid peptide, also known by its trade name. It is added to anti-ageing products with the idea of relaxing the muscle contraction tied to expression lines. Efficacy calls for caution. The manufacturer links it to smoothing and firmness, and there is some theoretical basis for its action on neuromuscular signalling, but independent data are scarce and small in scale. It is a support ingredient within an anti-ageing formula, without the solid backing of actives like retinoids or vitamin C. Do not expect injectable-neuromodulator-level results. Topically it has no systemic relevance, so it can be used during pregnancy and breastfeeding. Tolerance is good: low irritation and allergy potential, suitable for sensitive skin. It is one of the most comfortable peptide actives to add to a routine.
Frequently asked questions
Is Pentapeptide-18 safe during pregnancy?
Pentapeptide-18 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Pentapeptide-18 for?
Pentapeptide-18 suits: normal, dry, combination, oily, sensitive.
What is Pentapeptide-18 and what does it do in cosmetics?
A synthetic peptide.
What's the INCI name for Pentapeptide-18?
The INCI name is Pentapeptide-18. It may also appear as: Leuphasyl.
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