A synthetic muscle-relaxing peptide. The maker links it to smoothing expression lines; independent data are limited. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A synthetic peptide. Well tolerated; independent data limited.
Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate is a synthetic peptide that the cosmetic sector describes as a topical muscle relaxant (an expression-line "softener"). The manufacturer links it to smoother expression wrinkles by reducing the skin's repeated micro-contraction. On effectiveness it is worth keeping expectations measured. The idea of gently mimicking the botulinum toxin effect topically is appealing, but most of the data come from the manufacturer and independent evidence is scarce. It may give a modest visual improvement in fine lines with consistent use; it does not replace a medical procedure or match its result. Applied topically its systemic absorption is minimal, so it can be used during pregnancy and breastfeeding. Tolerability is good, with low irritation and allergy potential. It suits sensitive skin and is usually applied without discomfort at use levels.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate suits: normal, dry, combination, oily, sensitive.
A synthetic muscle-relaxing peptide.
The INCI name is Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate. It may also appear as: Тетрадецил аминобутироилвалиламиномасляная мочевина трифторацетат, SYN-AKE.
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