Ethylbisiminomethylguaiacol Manganese Chloride
An enzyme-mimic antioxidant (EUK-134). It mimics enzymes that neutralize free radicals and supports skin defense. Well tolerated.
Evidence by route
Topical application
An antioxidant component. Safe.
- CIR Cosmetic Ingredient Review safety assessment
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Combination, Oily, Sensitive
About this ingredient
Ethylbisiminomethylguaiacol manganese chloride (INCI Ethylbisiminomethylguaiacol Manganese Chloride), known as EUK-134, is a synthetic manganese complex. It mimics the action of antioxidant enzymes such as superoxide dismutase and catalase, so it helps neutralize free radicals and hydrogen peroxide in the skin. It enters the formula as an antioxidant active. On efficacy, it is an active with a plausible mechanism and in vitro data backing its antioxidant action. Clinical evidence in humans is still limited, so it is reasonable to expect support for antioxidant defense rather than a marked anti-aging effect. Applied topically it has no systemic relevance, so it can be used during pregnancy and breastfeeding. Tolerance is good, with low irritation and allergy potential, suitable for sensitive skin. Already-sensitized people may see an occasional reaction, though most do not.
Frequently asked questions
Is Ethylbisiminomethylguaiacol Manganese Chloride safe during pregnancy?
Ethylbisiminomethylguaiacol Manganese Chloride is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Ethylbisiminomethylguaiacol Manganese Chloride for?
Ethylbisiminomethylguaiacol Manganese Chloride suits: normal, dry, combination, oily, sensitive.
What is Ethylbisiminomethylguaiacol Manganese Chloride and what does it do in cosmetics?
An enzyme-mimic antioxidant (EUK-134).
What's the INCI name for Ethylbisiminomethylguaiacol Manganese Chloride?
The INCI name is Ethylbisiminomethylguaiacol Manganese Chloride. It may also appear as: EUK-134.
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