INCI: Acetylarginyltryptophyl Diphenylglycine
A synthetic peptide (Argireline). The maker links it to smoothing expression lines; independent data are limited. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A synthetic peptide. Safe; independent data limited.
Acetylarginyltryptophyl Diphenylglycine (INCI identical), known commercially as Argireline, is a synthetic peptide very common in anti-ageing cosmetics. It is marketed for its claimed ability to soften expression wrinkles by interfering with neurotransmitter release. Efficacy deserves a careful read. The manufacturer links it to smoothing expression lines, and there are small studies, many industry-funded, showing modest effects. Independent evidence is limited, so it counts as a support ingredient: it may contribute, without matching an injectable neuromodulator. Topically it has no systemic relevance, so it can be used during pregnancy and breastfeeding. Tolerance is good, with low irritation and allergy potential. It suits sensitive skin and is easy to add to serums and creams.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Acetyl Arginyltryptophyl Diphenylglycine is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Acetyl Arginyltryptophyl Diphenylglycine suits: normal, dry, combination, oily, sensitive.
A synthetic peptide (Argireline).
The INCI name is Acetylarginyltryptophyl Diphenylglycine. It may also appear as: Ацетиларгинилтриптофил дифенилглицин, Argireline, Аргирелин.
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