Acetyl Arginyltryptophyl Diphenylglycine
A synthetic peptide (Argireline). The maker links it to smoothing expression lines; independent data are limited. Well tolerated.
Evidence by route
Topical application
A synthetic peptide. Safe; independent data limited.
- CIR Cosmetic Ingredient Review safety assessment
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Combination, Oily, Sensitive
About this ingredient
Acetylarginyltryptophyl Diphenylglycine (INCI identical), known commercially as Argireline, is a synthetic peptide very common in anti-ageing cosmetics. It is marketed for its claimed ability to soften expression wrinkles by interfering with neurotransmitter release. Efficacy deserves a careful read. The manufacturer links it to smoothing expression lines, and there are small studies, many industry-funded, showing modest effects. Independent evidence is limited, so it counts as a support ingredient: it may contribute, without matching an injectable neuromodulator. Topically it has no systemic relevance, so it can be used during pregnancy and breastfeeding. Tolerance is good, with low irritation and allergy potential. It suits sensitive skin and is easy to add to serums and creams.
Frequently asked questions
Is Acetyl Arginyltryptophyl Diphenylglycine safe during pregnancy?
Acetyl Arginyltryptophyl Diphenylglycine is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Acetyl Arginyltryptophyl Diphenylglycine for?
Acetyl Arginyltryptophyl Diphenylglycine suits: normal, dry, combination, oily, sensitive.
What is Acetyl Arginyltryptophyl Diphenylglycine and what does it do in cosmetics?
A synthetic peptide (Argireline).
What's the INCI name for Acetyl Arginyltryptophyl Diphenylglycine?
The INCI name is Acetylarginyltryptophyl Diphenylglycine. It may also appear as: Argireline.
See Acetyl Arginyltryptophyl Diphenylglycine in a product composition right on the store page
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Similar role in the formula
Explore by category
Published: · updated: