Gluconolactone (PHA)
INCI: Gluconolactone
Polyhydroxy acid (PHA) – a gentle AHA alternative. Its large molecular size slows penetration, reducing irritation. Also hydrates through hygroscopicity.
Anti-agingMoisturizingBrightening
Evidence by route
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Small clinical studies show exfoliating and moisturizing effects comparable to glycolic acid with significantly less irritation. Evidence base is weaker than for AHAs. No independent large RCTs.
- Grimes PE et al. Cutis. 2004;73(2 Suppl):14-19.
Working concentrations
4–15%
Tolerability and safety
Irritation potential
LowAllergen risk
LowPregnancy
CautionSkin types
Suitable for
SensitiveDryNormalCombination
Frequently asked questions
Is Gluconolactone (PHA) safe during pregnancy?
Gluconolactone (PHA) should be used with caution during pregnancy. Consulting a dermatologist or OB-GYN is advisable.
What skin types is Gluconolactone (PHA) for?
Gluconolactone (PHA) suits: sensitive, dry, normal, combination.