Palmitoyl Dipeptide-7
Lipopeptide with palmitic acid for better penetration. Claimed soothing effect.
Evidence by route
Topical application
Marketing peptide without independent clinical data.
How to read tiers A–F
- DNo data, or very weak or conflicting data
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Caution
- Suitable for
- Normal, Dry, Oily, Combination, Sensitive
About this ingredient
Palmitoyl Dipeptide-7 is a synthetic lipopeptide: the L-alanyl-L-threonine dipeptide with an attached palmitic acid. The palmitoyl moiety enables penetration through the lipophilic skin barrier. Mechanism. Claimed action – blockade of the α-MSH receptor in melanocytes – reduces melanin production and lightens hyperpigmentation. Based on manufacturer studies. Where applied. Brightening serums and creams. Formula concentration 0.01–0.1% (as part of peptide complexes). Evidence base. Independent clinical RCTs are few. The evidence base is inferior to niacinamide, N-acetyl glucosamine, MAP. CIR has not published a separate assessment. Safety. Hypoallergenic at cosmetic concentrations, non-comedogenic. Pregnancy and lactation – manufacturers advise caution. No direct pregnancy data – synthetic palmitoyl peptides have not been studied in detail.
Frequently asked questions
Is Palmitoyl Dipeptide-7 safe during pregnancy?
Palmitoyl Dipeptide-7 should be used with caution during pregnancy. Consulting a dermatologist or OB-GYN is advisable.
What skin types is Palmitoyl Dipeptide-7 for?
Palmitoyl Dipeptide-7 suits: normal, dry, oily, combination, sensitive.
What is Palmitoyl Dipeptide-7 and what does it do in cosmetics?
Lipopeptide with palmitic acid for better penetration.
What's the INCI name for Palmitoyl Dipeptide-7?
The INCI name is Palmitoyl Dipeptide-7.
See Palmitoyl Dipeptide-7 in a product composition right on the store page
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
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