Schisandra Chinensis Extract

Tolerability and safety

Irritation potential

Low

Allergen risk

Low

Pregnancy

Unknown

About this ingredient

Schisandra chinensis extract is an extract from berries of wild schisandra, a vine from northern China, the Russian Far East, Korea. Active compounds: lignans (schisandrin, schisandrol, gomisin), triterpenes, flavonoids, organic acids. In traditional East Asian medicine schisandra is classified as an adaptogen – a substance to increase stress resilience. Where applied. Anti-aging serums and creams with 'adaptogen for skin' marketing (0.1-2%), products against photoaging, anti-pollution formulas, products for tired stressed skin. On the Spanish market – in niche natural and K-beauty lines. Evidence base. Systemic (oral) schisandra studies covered stress adaptation, physical exertion, mild cognitive impairment. Cochrane 2010 adaptogen review showed weak and inconsistent evidence quality. Topical clinical RCTs in humans with schisandra extract are isolated; antioxidant potential is proven in vitro. Marketing vs reality. The 'pollution defense' and 'adaptogen for skin' marketing in commercial formulas rests on in vitro data and the general reputation of systemic use. Real clinical skin effects are poorly studied. Safety. EU CosIng permits use. Systemically with oral intake schisandra causes heartburn, insomnia, tachycardia in some patients – topically no such effects, systemic absorption is minimal. Allergic reactions are rare. Pregnancy and lactation – use with caution. Systemically schisandra is contraindicated in pregnancy (uterine stimulation, psychotropic activity). Topically on intact skin systemic absorption is essentially absent, but due to lack of data manufacturers recommend avoiding. Alternatives: niacinamide, peptides, vitamin E.

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