Sodium PCA
Sodium salt of pyrrolidone carboxylic acid – the primary component of the natural moisturizing factor (NMF). Attracts and retains moisture in the stratum corneum.
Evidence by route
Topical application
Moisturizing effect confirmed by clinical data in xerosis. As an NMF component, it is highly skin-compatible. No standalone large RCTs – typically used in combination with other humectants.
- Rawlings AV, Harding CR. Trends in stratum corneum research and the management of dry skin conditions. Int J Cosmet Sci. 2003;25(1-2):63-95. DOI 10.1046/j.1467-2494.2003.00174.x
How to read tiers A–F
- CWeak evidence. In vitro data, open-label studies, or expert consensus
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Oily, Dry, Sensitive, Combination, Normal
About this ingredient
Sodium PCA is the sodium salt of pyrrolidone carboxylic acid, the primary component of the stratum corneum natural moisturizing factor (NMF). PCA accounts for about 12% of healthy-skin NMF. Its levels drop with age and in atopic dermatitis. Mechanism. A powerful humectant: the molecule is hygroscopic and binds 2-3 times more water than glycerin at equivalent concentration. Maintains stratum corneum elasticity and supports acidic barrier pH. Sodium PCA leaves no film and no greasy residue. Where applied. Serums, toners, light emulsions (0.5-5%), oily and combination-skin products. In Spain – Sesderma Hidraderm Hyal, Isdin Hyaluronic Concentrate, Eucerin Hyaluron-Filler, CeraVe Hydrating Toner. Evidence base. 30% hydration gain in 4 weeks at 2% (Verdier-Sevrain 2007), TEWL reduction in atopics. Sodium PCA pairs well with hyaluronic acid and amino acids for a synergistic NMF complex. Safety. CIR confirmed safety up to 50%. Hypoallergenic, non-comedogenic. No systemic absorption through intact skin. Pregnancy and lactation – safe. Applicable at any stage and on any area, including face, breast, abdomen.
Frequently asked questions
Is Sodium PCA safe during pregnancy?
Sodium PCA is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Sodium PCA for?
Sodium PCA suits: oily, dry, sensitive, combination, normal.
What is Sodium PCA and what does it do in cosmetics?
Sodium salt of pyrrolidone carboxylic acid – the primary component of the natural moisturizing factor (NMF).
What's the INCI name for Sodium PCA?
The INCI name is Sodium PCA. It may also appear as: PCA Salt.
See Sodium PCA in a product composition right on the store page
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