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Vitis Vinifera (Grape) Fruit Extract

Grape fruit extract. Contains resveratrol, proanthocyanidins and polyphenols – antioxidants with confirmed in vitro activity. At concentrations typical for cosmetics (<1%), the clinical skin effect is modest. Safe, hypoallergenic.

INCI: Vitis Vinifera Fruit Extract

Evidence by route

C

Topical application

Antioxidant profile confirmed in vitro. Clinical RCTs of topical resveratrol show a mild effect on pigmentation and fine lines with long-term use.

  • Farris P et al. A novel topical antioxidant blend with resveratrol. JDD 2014. PMID 25607790
How to read tiers A–F
  • CWeak evidence. In vitro data, open-label studies, or expert consensus

Tolerability and safety

Irritation potential
Low
Allergen risk
Low
Pregnancy
Safe
Suitable for
Normal, Dry, Combination, Oily, Sensitive

About this ingredient

Vitis Vinifera Fruit Extract is an extract from grape berries. Contains resveratrol, proanthocyanidins, quercetin, anthocyanins, tartaric acid, phenolic acids – a polyphenol group with confirmed in vitro antioxidant activity. Mechanism. Grape polyphenols neutralise free radicals and suppress NF-κB activation, reducing inflammation. Resveratrol activates SIRT1 – a cellular longevity gene. In vitro it suppresses MMP-1 (collagenase) and stimulates collagen synthesis in fibroblasts. Clinical effects at cosmetic concentrations are modest – most studies are on oral forms. Where applied. Caudalie – a Spanish-French brand built entirely on grape polyphenols. Common in Spain: Caudalie Vinosource, Sesderma Resveraderm, La Roche-Posay Anthelios with grape extract. Use levels: 0.1-1%. Evidence base. In vitro – robust. Few clinical RCTs with 'wrinkle reduction' endpoints for topical use exist. Buonocore 2012 in an open study of 60 women showed improved firmness and radiance over 6 months of 1% resveratrol complex use. Safety. CIR confirmed safety. Sensitises rarely, non-comedogenic. Rare allergy possible in patients with oral grape reactions. Pregnancy and lactation – safe. Topical systemic absorption is minimal. Suited for. Mature skin with photoageing signs, anti-ageing prevention in young patients, eczema and rosacea (mild anti-inflammatory effect).

Frequently asked questions

Is Vitis Vinifera (Grape) Fruit Extract safe during pregnancy?

Vitis Vinifera (Grape) Fruit Extract is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.

What skin types is Vitis Vinifera (Grape) Fruit Extract for?

Vitis Vinifera (Grape) Fruit Extract suits: normal, dry, combination, oily, sensitive.

What is Vitis Vinifera (Grape) Fruit Extract and what does it do in cosmetics?

Grape fruit extract.

What's the INCI name for Vitis Vinifera (Grape) Fruit Extract?

The INCI name is Vitis Vinifera Fruit Extract. It may also appear as: Grape Fruit Extract.

See Vitis Vinifera (Grape) Fruit Extract in a product composition right on the store page

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