Vitis Vinifera Seed Extract
Grape seed extract, a source of oligomeric proanthocyanidins. Antioxidant activity in lab models, mild astringent effect.
Evidence by route
Topical application
Antioxidant potential confirmed in vitro. Clinical data for topical anti-age effects are limited to small studies.
- Sharif A et al. Int J Cosmet Sci. 2015;37(2):253-8. PMID 25402429
How to read tiers A–F
- CWeak evidence. In vitro data, open-label studies, or expert consensus
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Oily, Combination, Dry
- Use with caution
- Sensitive
About this ingredient
Vitis Vinifera Seed Extract is an extract from grape seeds. Rich in oligomeric proanthocyanidins (OPC) – a polyphenol group with antioxidant activity 20-50 times stronger than vitamin C in vitro. Also contains resveratrol (lower than in the skin), quercetin, catechins. Mechanism. OPC bind free radicals, inhibit lipid peroxidation, stabilise collagen and elastin. Mild astringent effect via tannins. In vitro they suppress MMP-1 and MMP-9 (collagenases) activation. Where applied. Caudalie Vinosource (central brand ingredient), Sesderma Resveraderm Antiox, anti-ageing serums and creams. In Spain – widely in Caudalie, Skeyndor, Mesoestetic. Use levels: 0.1-2%. Evidence base. Pataki 2002 RCT in 28 patients over 8 weeks of OPC use showed reduced wrinkle depth and improved firmness. Head-to-head comparisons with vitamin C or retinol have not been done. Most data come from oral forms in varicose disease (Cochrane 2019 – moderate evidence base). Safety. CIR confirmed safety. Sensitises rarely, non-comedogenic. Tannins above 3% can cause tightness and dryness – not recommended for sensitive skin. Pregnancy and lactation – safe. Topical systemic absorption is minimal. Suited for. Mature skin, anti-ageing prevention, photoprotective support (as a sunscreen add-on), mild anti-ageing for those who do not tolerate retinoids.
Frequently asked questions
Is Vitis Vinifera Seed Extract safe during pregnancy?
Vitis Vinifera Seed Extract is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Vitis Vinifera Seed Extract for?
Vitis Vinifera Seed Extract suits: normal, oily, combination, dry. Use with caution in: sensitive.
What is Vitis Vinifera Seed Extract and what does it do in cosmetics?
Grape seed extract, a source of oligomeric proanthocyanidins.
What's the INCI name for Vitis Vinifera Seed Extract?
The INCI name is Vitis Vinifera Seed Extract. It may also appear as: Grape Seed Extract.
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