Lactobacillus Extracellular Vesicles
Next-generation postbiotic – nanovesicles secreted by Lactobacillus into the medium during cultivation. Carry proteins, lipids and microRNAs of the parent cell, without live bacteria. In vitro studies show anti-inflammatory potential on keratinocytes and immune cells. Few human clinical RCTs so far.
Evidence by route
Topical application
Promising postbiotic component. Mechanism – modulation of keratinocyte inflammatory response via microRNA cargo. Clinical RCTs are limited, most data come from in vitro and animal models.
- Kim MH et al. Allergy Asthma Immunol Res. 2018;10(5):516-532. PMID 30088371
How to read tiers A–F
- CWeak evidence. In vitro data, open-label studies, or expert consensus
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Caution
- Suitable for
- Normal, Dry, Combination, Oily, Sensitive
About this ingredient
Lactobacillus Extracellular Vesicles (EVs) are 30–200 nm nanovesicles secreted by Lactobacillus bacteria into culture medium. They carry cell-wall proteins, phospholipids and parent-cell microRNAs but contain no live microorganisms. Mechanism. In vitro studies show EVs reduce pro-inflammatory cytokines (IL-6, TNF-α) in HaCaT keratinocytes (Kim 2020, Park 2022) and suppress NF-κB activation. Claimed effect – skin barrier and microbiome support without the risks of live probiotics. Where applied. Korean recovery serums and creams for sensitive skin – Mediheb, Aestura, Manyo Factory. Still rare in Europe, only premium niche serums. Formula concentrations are not disclosed. Evidence base. Human RCTs are few (n<50) and in vivo effect has not been confirmed in independent work. CIR and SCCS have not published a separate assessment – the ingredient is reviewed as part of postbiotic cultures. Pregnancy and lactation data are absent; manufacturers recommend avoidance as a novel technology with limited clinical base. Alternative for sensitive skin in pregnancy – niacinamide, panthenol, centella.
Frequently asked questions
Is Lactobacillus Extracellular Vesicles safe during pregnancy?
Lactobacillus Extracellular Vesicles should be used with caution during pregnancy. Consulting a dermatologist or OB-GYN is advisable.
What skin types is Lactobacillus Extracellular Vesicles for?
Lactobacillus Extracellular Vesicles suits: normal, dry, combination, oily, sensitive.
What is Lactobacillus Extracellular Vesicles and what does it do in cosmetics?
Next-generation postbiotic – nanovesicles secreted by Lactobacillus into the medium during cultivation.
What's the INCI name for Lactobacillus Extracellular Vesicles?
The INCI name is Lactobacillus Extracellular Vesicles. It may also appear as: Lactobacillus EVs, Postbiotic Vesicles.
See Lactobacillus Extracellular Vesicles in a product composition right on the store page
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