A synthetic tripeptide. The maker links it to firmness and smoothing; data are limited. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A synthetic peptide. Well tolerated; data limited.
Tripeptide-3 (INCI: Tripeptide-3) is a synthetic three-amino-acid peptide included in anti-aging formulas. The marketing idea is that it acts as a signaling molecule to support firmness and a smoother skin appearance. It is worth being clear here: the evidence is thin. Unlike better-studied peptides, Tripeptide-3 has little published clinical data to back those effects. It is best taken as a supporting ingredient with a modest basis, not an anti-aging active with proven results. Anyone after firmness with solid backing will get more from retinoids or vitamin C. Applied topically it poses no systemic risk, so it can be used during pregnancy and breastfeeding. The described tolerance is good, with low irritation potential and low allergy risk. It suits sensitive skin and has no notable comedogenic profile.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Tripeptide-3 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Tripeptide-3 suits: normal, dry, combination, oily, sensitive.
A synthetic tripeptide.
The INCI name is Tripeptide-3. It may also appear as: Трипептид-3.
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