Spanish molecular cosmetics, high-concentration actives
41 products in the database · compositions verified against the manufacturer
Singuladerm started in 2009 as the first brand from the Spanish laboratory Prima·Derm, based in Gavà near Barcelona. Chemist Dr. García Antón founded it after years in the pharmaceutical industry, and it sold through pharmacies under one guiding idea: molecular cosmetics, formulas built around high concentrations of active ingredients and delivery methods such as nanoencapsulation.
Its best-known range is XPERT. It includes the XPERT SOS ampoules dosed with a high percentage of Argireline, XPERT Expression with Argireline and Leuphasyl, and XPERT Collageneur, aimed at expression lines and firmness. The brand also works with vitamin C derivatives and biotech peptides, and it tends to state the concentration of its actives, which many brands leave out.
In 2024 Singuladerm rebranded to Primaderm while keeping the same formulas; plenty of products still circulate under the Singuladerm name in pharmacies and online shops.
On this Evigrade page you can browse the brand's products with their full INCI list and each ingredient rated by level of evidence (traffic-light plus an A–F tier), along with pregnancy-use notes. Evigrade is an independent, evidence-based reference for cosmetic composition, not a shop and not medical advice.
41 products · 217 ingredients across the formulas · 141 rated green for evidence
Tier A–B ingredients by evidence that appear in this brand's formulas. Each links to its full breakdown.
Balance Cleansing Gel 200ml
17 recognized / 18 ingredients
Biodefense Prebiotic Cream m/g 50ml
24 recognized / 24 ingredients
Biodefense Prebiotic Cream n/s 50ml
29 recognized / 29 ingredients
Biodefense Prebiotic Mask 50ml
20 recognized / 21 ingredients
Biodefense Prebiotic Serum 50ml
14 recognized / 15 ingredients
Deep Cleansing Oil-to-milk 200ml
16 recognized / 17 ingredients
Singuladerm is a Spanish pharmacy dermocosmetics brand known for high concentrations of actives, especially peptides like Argireline. Whether it suits you depends on your skin and the specific product; on this page you can check each product's INCI and the evidence level of its ingredients.
Yes. The brand rebranded to Primaderm in 2024 while keeping the same formulas. Many products still sell under the Singuladerm name in pharmacies and online.
It sells mainly through pharmacies, online and physical, and dermocosmetics shops. Evigrade does not sell products; here you only find the brand's composition analysis.
It depends on the formula and your tolerance, since some products carry strong actives at high concentrations. Check the full INCI for each product here and consult a professional if your skin is reactive.
Pharmacy dermocosmetics · Other brands