Evigrade

Singuladerm

Spanish molecular cosmetics, high-concentration actives

Origin: SpainFounded: 2009Group: Prima-Derm, S.L.41 products in the database · compositions verified against the manufacturer

All products by this brand

High-evidence actives found in the formulas

Tier A–B ingredients by evidence that appear in this brand's formulas. Each links to its full breakdown

What this page covers

Singuladerm started in 2009 as the first brand from the Spanish laboratory Prima·Derm, based in Gavà near Barcelona. Chemist Dr. García Antón founded it after years in the pharmaceutical industry, and it sold through pharmacies under one guiding idea: molecular cosmetics, formulas built around high concentrations of active ingredients and delivery methods such as nanoencapsulation.

Its best-known range is XPERT. It includes the XPERT SOS ampoules dosed with a high percentage of Argireline, XPERT Expression with Argireline and Leuphasyl, and XPERT Collageneur, aimed at expression lines and firmness. The brand also works with vitamin C derivatives and biotech peptides, and it tends to state the concentration of its actives, which many brands leave out.

In 2024 Singuladerm rebranded to Primaderm while keeping the same formulas; plenty of products still circulate under the Singuladerm name in pharmacies and online shops.

On this Evigrade page you can browse the brand's products with their full INCI list and each ingredient rated by level of evidence (traffic-light plus an A–F tier), along with pregnancy-use notes. Evigrade is an independent, evidence-based reference for cosmetic composition, not a shop and not medical advice.

217 ingredients across the formulas · 139 rated green for evidence

Frequently asked

Is Singuladerm a good brand?

Singuladerm is a Spanish pharmacy dermocosmetics brand known for high concentrations of actives, especially peptides like Argireline. Whether it suits you depends on your skin and the specific product; on this page you can check each product's INCI and the evidence level of its ingredients.

Is Singuladerm now Primaderm?

Yes. The brand rebranded to Primaderm in 2024 while keeping the same formulas. Many products still sell under the Singuladerm name in pharmacies and online.

Where can I buy Singuladerm?

It sells mainly through pharmacies, online and physical, and dermocosmetics shops. Evigrade does not sell products; here you only find the brand's composition analysis.

Are Singuladerm products fine for sensitive skin?

It depends on the formula and your tolerance, since some products carry strong actives at high concentrations. Check the full INCI for each product here and consult a professional if your skin is reactive.

Pharmacy dermocosmetics · Other brands

ISDIN, Nuxe, Avène, La Roche-Posay, Klorane, Sesderma, Caudalie, Ducray

Official site · Singuladerm