Arginine PCA
A humectant from the amino acid arginine. It holds water in the skin and gently sets the formula pH. Well tolerated.
Evidence by route
Topical application
A functional humectant. Safe, well tolerated.
- CIR Cosmetic Ingredient Review safety assessment
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Combination, Oily, Sensitive
About this ingredient
Arginine PCA (INCI: Arginine PCA) is a hydrating ingredient made of the amino acid arginine bound to pyrrolidone carboxylic acid (PCA), part of the skin's natural moisturizing factor. In formulas it attracts and holds water and also helps fine-tune the pH. As an active it is a reasonable supporting humectant. PCA is part of the skin's natural hydration system, so the water-binding effect has a basis; still, its contribution is modest and it works better alongside other humectants than on its own. Topically there is no meaningful systemic exposure, so it can be used during pregnancy and breastfeeding. Tolerance is good: irritation and allergy risk are both low. It fits hydrating formulas for sensitive skin, where it adds comfort without pulling at the barrier.
Frequently asked questions
Is Arginine PCA safe during pregnancy?
Arginine PCA is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Arginine PCA for?
Arginine PCA suits: normal, dry, combination, oily, sensitive.
What is Arginine PCA and what does it do in cosmetics?
A humectant from the amino acid arginine.
What's the INCI name for Arginine PCA?
The INCI name is Arginine PCA. It may also appear as: Arginine Pyrrolidone Carboxylate.
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