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Bifida Ferment Lysate

A lysate of bifidobacteria. In one randomized trial by a cosmetics company, a cream with 10% lysate lowered sensitivity of reactive skin and made the barrier more resistant. Anti-aging effects have not been studied

Evidence by route

B

Topical application

One placebo-controlled randomized trial by a cosmetics company tested a cream with 10% lysate in women with reactive skin for two months. Sensitivity fell and the barrier became more resistant. There is no independent replication, and the abstract gives no effect sizes. Anti-aging effects have not been studied

  • Guéniche A et al. Bifidobacterium longum lysate, a new ingredient for reactive skin. Exp Dermatol. 2010;19(8):e1-8. PMID 19624730
  • Wang R et al. The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro. J Cosmet Dermatol. 2023;22(12):3427-3435. PMID 37218728
How to read tiers A–F
  • BLimited evidence. One RCT or several controlled studies with limitations

Tolerability and safety

Working concentrations
The only human trial used a cream with 10% lysate for two months (Guéniche 2010). Lower concentrations, 0.3–1%, were tested only on nerve cell cultures. There are no human data below 10%
Irritation potential
Low
Allergen risk
Low
Pregnancy
Unknown
Suitable for
Normal, Dry, Combination, Sensitive

About this ingredient

Bifida Ferment Lysate is a lysate of bifidobacteria after fermentation: inactivated cells and their contents. It goes into serums and creams for sensitive skin and into anti-aging serums. In HaCaT keratinocytes the lysate raised expression of barrier genes such as filaggrin and of antimicrobial peptides. It also reduced oxidative damage. In macrophages it lowered IL-8 and TNF-α (Wang 2023). A Bifidobacterium longum lysate at 0.3–1% reduced CGRP release from nerve cells. On human skin explants, it reduced vasodilation, edema and TNF-α release (Guéniche 2010). These are lab data. Employees of a cosmetics company ran the only controlled human trial (Guéniche 2010). In this double-blind study, 66 women with reactive skin used a cream with 10% B. longum lysate or placebo twice daily for two months. By the end, sensitivity in the lactic acid stinging test fell and more tape strips were needed to disrupt the barrier. Dryness was lower at day 29. The abstract reports p values without effect sizes. It does not name the INCI, though the raw material is most likely Bifida Ferment Lysate. There is no independent replication. Lower concentrations have not been tested in people. Claims about night-time DNA repair, photolyase-like action and recovery after UV were not found in peer-reviewed literature. Anti-aging effects have not been studied. There are no published data on irritation or allergy and no data on use during pregnancy and breastfeeding.

Frequently asked questions

Is Bifida Ferment Lysate safe during pregnancy?

Safety data for Bifida Ferment Lysate during pregnancy is insufficient. Best avoided when in doubt.

What skin types is Bifida Ferment Lysate for?

Bifida Ferment Lysate suits: normal, dry, combination, sensitive.

What is Bifida Ferment Lysate and what does it do in cosmetics?

A lysate of bifidobacteria.

What's the INCI name for Bifida Ferment Lysate?

The INCI name is Bifida Ferment Lysate. It may also appear as: Bifidobacterium Ferment Lysate.

What concentration of Bifida Ferment Lysate is effective?

The only human trial used a cream with 10% lysate for two months (Guéniche 2010). Lower concentrations, 0.3–1%, were tested only on nerve cell cultures. There are no human data below 10%

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