Hydroxyacetophenone
Antioxidant preservative booster. Reduces formula oxidation and strengthens the activity of other antimicrobial components.
Evidence by route
Topical application
Tolerates well and stabilizes active formulas. Frequent ingredient in vitamin C and ferulic acid serums.
How to read tiers A–F
- CWeak evidence. In vitro data, open-label studies, or expert consensus
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Oily, Combination, Sensitive
About this ingredient
Hydroxyacetophenone (4-Hydroxyacetophenone) is an aromatic compound, antioxidant booster for preservatives. Produced synthetically from acetophenone. Mechanism. Scavenges free radicals and stabilizes the formula against oxidation. Boosts the efficacy of other preservatives (phenoxyethanol, benzoic acid) – allowing them to be used at lower concentrations and broadening antimicrobial coverage. Especially valued for "clean beauty" paraben-free formulas. Where applied. Serums, creams, emulsions (0.2-1%). Often in lines labeled "paraben-free" and "clean beauty". In Spain in The Ordinary formulas (distributed via Sephora and Druni), Caudalie, Rilastil, Sesderma C-Vit. Evidence base. Industry research (Symrise, Sederma) confirms synergy with phenoxyethanol and reduction of TBARS oxidation marker in the formula. There is no direct skin effect – this is a technological ingredient. Safety. CIR rated hydroxyacetophenone safe at cosmetic concentrations (2010, re-evaluated 2019). Irritation and allergic reactions are rare; isolated cases of contact allergy reported (Aerts 2017). Pregnancy and lactation – safe topically. Suitable for all skin types.
Frequently asked questions
Is Hydroxyacetophenone safe during pregnancy?
Hydroxyacetophenone is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Hydroxyacetophenone for?
Hydroxyacetophenone suits: normal, dry, oily, combination, sensitive.
What is Hydroxyacetophenone and what does it do in cosmetics?
Antioxidant preservative booster.
What's the INCI name for Hydroxyacetophenone?
The INCI name is Hydroxyacetophenone. It may also appear as: 4'-Hydroxyacetophenone.
See Hydroxyacetophenone in a product composition right on the store page
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