Palmitoyl Tripeptide-8
Biomimetic peptide with anti-inflammatory activity for sensitive skin (Neutrazen). Functional formulation ingredient with no standalone activity on the skin.
Evidence by route
Topical application
Manufacturer claims an anti-inflammatory effect via α-MSH mimicking. Independent clinical evidence is limited; data are mostly in vitro or vendor-sponsored.
How to read tiers A–F
- CWeak evidence. In vitro data, open-label studies, or expert consensus
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
About this ingredient
Palmitoyl Tripeptide-8 (Neutrazen) is a synthetic lipopeptide: the tripeptide His-D-Phe-Arg with palmitic acid. An α-MSH hormone analog with anti-inflammatory focus. Mechanism. Binds to MC1R receptors on keratinocytes and suppresses neurogenic inflammation. Reduces CGRP and substance P production – neuropeptides causing redness and burning in rosacea and sensitive skin. Where applied. Serums and creams for rosacea, sensitive skin, couperose, post-procedure recovery products. Concentration 2–8 ppm. In Skeyndor, Sesderma, Endocare Rosatum. Evidence base. Bohbot 2007 RCT (n=20) showed reduced redness and improved skin comfort in rosacea over 4 weeks at 4 ppm. No systematic review. Evidence base is smaller than for brimonidine and metronidazole, but the peptide is in demand in the cosmetic niche. Safety. CIR confirmed safety. Hypoallergenic, non-comedogenic, does not photosensitize. Pregnancy and lactation – topically safe per manufacturers. No direct pregnancy data, but local use at cosmetic concentrations is not systemically significant.
Frequently asked questions
Is Palmitoyl Tripeptide-8 safe during pregnancy?
Palmitoyl Tripeptide-8 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What is Palmitoyl Tripeptide-8 and what does it do in cosmetics?
Biomimetic peptide with anti-inflammatory activity for sensitive skin (Neutrazen).
What's the INCI name for Palmitoyl Tripeptide-8?
The INCI name is Palmitoyl Tripeptide-8. It may also appear as: Neutrazen.
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