Hydroxypinacolone Retinoate
Retinoic acid ester known under the brand Granactive Retinoid. Irritates the skin less than retinol but also has a noticeably smaller clinical base.
Evidence by route
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
A newer retinoid that binds retinoic acid receptors directly. Manufacturer studies show results comparable to retinol, but large independent RCTs are still few.
Tolerability and safety
Irritation potential
MediumAllergen risk
LowPregnancy
AvoidSkin types
Suitable for
Use with caution
Frequently asked questions
Is Hydroxypinacolone Retinoate safe during pregnancy?
Hydroxypinacolone Retinoate is not recommended during pregnancy. Consider an alternative from the same category.
What skin types is Hydroxypinacolone Retinoate for?
Hydroxypinacolone Retinoate suits: oily, dry, combination, normal. Use with caution in: sensitive.
Can Hydroxypinacolone Retinoate irritate the skin?
Hydroxypinacolone Retinoate has moderate irritation potential. Sensitive skin may show a transient reaction that usually settles with adaptation.