A salt of the amino acid histidine. It supports hydration and joins a recovery complex. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
An amino acid that supports hydration. Safe.
Histidine HCl is a salt form of the amino acid histidine. INCI: Histidine HCl. In skin, histidine is part of the natural moisturizing factor and a source of urocanic acid, which takes part in stratum-corneum defense. The molecule also has mild antioxidant properties. In a formula it works as a humectant and conditioning agent, holding water and supporting skin comfort. Its standalone activity is mild; it is a supporting component. Pregnancy safety. Topical use, low systemic absorption, no evidence of harm. It can be used during pregnancy and lactation. Tolerance. Irritation and allergen potential are low, suitable for sensitive skin.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Histidine HCl is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Histidine HCl suits: normal, dry, combination, oily, sensitive.
A salt of the amino acid histidine.
The INCI name is Histidine HCl. It may also appear as: Гистидин гидрохлорид, Histidine Hydrochloride.
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