Histidine HCl
A salt of the amino acid histidine. It supports hydration and joins a recovery complex. Well tolerated.
Evidence by route
Topical application
An amino acid that supports hydration. Safe.
- CIR Cosmetic Ingredient Review safety assessment
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Combination, Oily, Sensitive
About this ingredient
Histidine HCl is a salt form of the amino acid histidine. INCI: Histidine HCl. In skin, histidine is part of the natural moisturizing factor and a source of urocanic acid, which takes part in stratum-corneum defense. The molecule also has mild antioxidant properties. In a formula it works as a humectant and conditioning agent, holding water and supporting skin comfort. Its standalone activity is mild; it is a supporting component. Pregnancy safety. Topical use, low systemic absorption, no evidence of harm. It can be used during pregnancy and lactation. Tolerance. Irritation and allergen potential are low, suitable for sensitive skin.
Frequently asked questions
Is Histidine HCl safe during pregnancy?
Histidine HCl is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Histidine HCl for?
Histidine HCl suits: normal, dry, combination, oily, sensitive.
What is Histidine HCl and what does it do in cosmetics?
A salt of the amino acid histidine.
What's the INCI name for Histidine HCl?
The INCI name is Histidine HCl. It may also appear as: Histidine Hydrochloride.
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