Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine
A synthetic lipopeptide. The maker links it to skin firmness and wrinkle smoothing; independent data are limited. Well tolerated.
Evidence by route
Topical application
A peptide active. The maker links it to skin firmness; independent data limited.
- CIR Cosmetic Ingredient Review safety assessment
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Combination, Oily, Sensitive
About this ingredient
Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine (INCI: Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine) is a synthetic signaling-type lipopeptide. The manufacturer links it to firmer skin and softened wrinkles, within anti-aging ranges. On efficacy, independent evidence is scarce; much of the backing comes from the supplier. It is reasonable to treat it as a supporting anti-aging component with modest results rather than an active with proven effect. It can sit within a routine without expecting a dramatic change on its own. Topically its systemic relevance is negligible, so it can be used during pregnancy and breastfeeding without special restriction. Tolerance is good. Irritation and allergy potential are low, suitable for sensitive skin. Most people show no reaction, and it is not linked to clogged pores.
Frequently asked questions
Is Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine safe during pregnancy?
Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine for?
Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine suits: normal, dry, combination, oily, sensitive.
What is Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine and what does it do in cosmetics?
A synthetic lipopeptide.
What's the INCI name for Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine?
The INCI name is Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine.
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