A synthetic lipopeptide. The maker links it to skin firmness and wrinkle smoothing; independent data are limited. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A peptide active. The maker links it to skin firmness; independent data limited.
Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine (INCI: Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine) is a synthetic signaling-type lipopeptide. The manufacturer links it to firmer skin and softened wrinkles, within anti-aging ranges. On efficacy, independent evidence is scarce; much of the backing comes from the supplier. It is reasonable to treat it as a supporting anti-aging component with modest results rather than an active with proven effect. It can sit within a routine without expecting a dramatic change on its own. Topically its systemic relevance is negligible, so it can be used during pregnancy and breastfeeding without special restriction. Tolerance is good. Irritation and allergy potential are low, suitable for sensitive skin. Most people show no reaction, and it is not linked to clogged pores.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine suits: normal, dry, combination, oily, sensitive.
A synthetic lipopeptide.
The INCI name is Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine. It may also appear as: Пальмитоил дипептид-5 диаминобутироил гидрокситреонин.
Published: · updated: