Dipeptide Diaminobutyroyl Benzylamide Diacetate
Synthetic peptide that the supplier modeled on waglerin-1, a viper venom peptide. No study has shown an effect on expression muscles. Human data come only from open-label studies of blends
Evidence by route
Topical application
There are no studies of this peptide on its own in people. Clinical data come only from open-label studies of multi-ingredient serums, where its contribution was not separated. The claimed mechanism, blockade of the muscle acetylcholine receptor, was shown for the venom peptide waglerin-1, not for this molecule
- Zhu M et al. The effect of a serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies. Int J Cosmet Sci. 2026;48(5):913-925. PMID 41668671
- Gok B et al. Anti-aging activity of Syn-Ake peptide by in silico approaches and in vitro tests. J Biomol Struct Dyn. 2024;42(10):5015-5029. PMID 37349941
How to read tiers A–F
- DNo data, or very weak or conflicting data
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Unknown
- Suitable for
- Normal, Dry, Combination, Oily, Sensitive
About this ingredient
Dipeptide diaminobutyroyl benzylamide diacetate (raw-material trade name SYN-AKE) is a small synthetic peptide. The diacetate has a molar mass of about 496 g/mol. The supplier modeled it on waglerin-1, a peptide from temple pit viper venom (Tropidolaemus wagleri). It is promoted as a muscle-relaxing ingredient for expression lines. Waglerin-1 blocks the nicotinic acetylcholine receptor of skeletal muscle. For the synthetic peptide, receptor binding appears only in unpublished supplier data. The snake-venom comparison therefore rests on another substance's mechanism. The one published lab study combined computer docking with a test-tube antioxidant assay and did not examine nerves or muscles (Gok 2024). There are no data on skin penetration. Human data come only from multi-ingredient serums. The manufacturer of one serum ran two open-label studies (50 and 42 people, 12 weeks). The serum contained acetyl hexapeptide-8, this peptide, gluconolactone, niacinamide and laminaria extract. Clinical scores improved by 35–69% for static wrinkles and by 10–13% for dynamic ones (Zhu 2026). No control group is described. The authors did not separate this peptide's contribution. Safety data are limited to laboratory cytotoxicity and Ames tests (Gok 2024). Human sensitization data are lacking. There are no data on use during pregnancy or breastfeeding.
Frequently asked questions
Is Dipeptide Diaminobutyroyl Benzylamide Diacetate safe during pregnancy?
Safety data for Dipeptide Diaminobutyroyl Benzylamide Diacetate during pregnancy is insufficient. Best avoided when in doubt.
What skin types is Dipeptide Diaminobutyroyl Benzylamide Diacetate for?
Dipeptide Diaminobutyroyl Benzylamide Diacetate suits: normal, dry, combination, oily, sensitive.
What is Dipeptide Diaminobutyroyl Benzylamide Diacetate and what does it do in cosmetics?
Synthetic peptide that the supplier modeled on waglerin-1, a viper venom peptide.
What's the INCI name for Dipeptide Diaminobutyroyl Benzylamide Diacetate?
The INCI name is Dipeptide Diaminobutyroyl Benzylamide Diacetate. It may also appear as: Syn-Ake, SYN-AKE, SYN-AKE (péptido de serpiente).
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