A signal peptide. The maker links it to collagen production and smoothing; independent data are limited. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A signal peptide. Well tolerated; independent data limited.
Palmitoyl Tripeptide-38 is a synthetic signal peptide linked to palmitic acid for better penetration, known by the trade name Matrixyl synthe'6. INCI: Palmitoyl Tripeptide-38. In a formula it works as an active with a claimed anti-aging action: it is linked to support of collagen synthesis and other dermal-matrix components, which helps reduce wrinkles. Among cosmetic peptides, the Matrixyl-line molecules have a relatively fair base, but mostly from manufacturer studies, and the effect is mild and needs time. It is a supporting active. Pregnancy safety. Topical use, low systemic absorption, no evidence of harm. It can be used during pregnancy and lactation. Tolerance. Irritation and allergen potential are low.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Palmitoyl Tripeptide-38 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Palmitoyl Tripeptide-38 suits: normal, dry, combination, oily, sensitive.
A signal peptide.
The INCI name is Palmitoyl Tripeptide-38. It may also appear as: Пальмитоил трипептид-38, Matrixyl Synthe-6.
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