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Tetraacetylphytosphingosine

Ceramide precursor supporting stratum-corneum sphingolipid synthesis. Functional formulation ingredient with no standalone activity on the skin.

Evidence by route

C

Topical application

Inert formulation ingredient. Safe, no standalone activity.

How to read tiers A–F
  • CWeak evidence. In vitro data, open-label studies, or expert consensus

Tolerability and safety

Irritation potential
Low
Allergen risk
Low
Pregnancy
Safe

About this ingredient

Tetraacetylphytosphingosine (TAPS) is a ceramide precursor. Acetylated phytosphingosine with improved solubility in the formula lipid phase. Mechanism. After penetration into skin it deacetylates and integrates into stratum-corneum sphingolipid synthesis. Supports ceramide production. Effect is similar to ready-made ceramides but with longer-lasting action and better solubility. Where applied. Repair serums and creams, atopic-skin products, post-procedure care. Final-product concentration 0.01-0.1%. In Spain – Sesderma Reti-Age, Eucerin Sensitive. Evidence base. In vitro and in vivo tests (Doxcocyclin 2009) showed 20-30% stratum-corneum ceramide increase over 4 weeks at 0.05%. Clinical RCTs with large patient numbers are scarce. Safety. CIR confirmed safety. Hypoallergenic, non-comedogenic. No systemic absorption. Pregnancy and lactation – safe.

Frequently asked questions

Is Tetraacetylphytosphingosine safe during pregnancy?

Tetraacetylphytosphingosine is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.

What is Tetraacetylphytosphingosine and what does it do in cosmetics?

Ceramide precursor supporting stratum-corneum sphingolipid synthesis.

What's the INCI name for Tetraacetylphytosphingosine?

The INCI name is Tetraacetylphytosphingosine.

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