A soothing active for reactive skin. It lowers sensitivity to heat and irritants via the TRPV1 receptor. Suits sensitive skin.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A soothing active. Safe.
Trans-4-tert-Butylcyclohexanol is a synthetic active known by the trade name SymSitive. INCI: Trans-4-tert-Butylcyclohexanol. It was developed for sensitive and redness-prone skin. In a formula it works as a soothing component: it lowers the activity of the TRPV1 receptor, through which skin senses irritation and heat, so it helps reduce stinging, burning, and neurogenic redness. As an active against sensitivity and rosacea it has a fair research base, including from the developing brand. It is a useful supporting active for reactive skin. Pregnancy safety. Topical use is systemically negligible, with no evidence of harm. It can be used during pregnancy and lactation. Tolerance. Irritation and allergen potential are low, suitable for sensitive skin.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Trans-4-tert-Butylcyclohexanol is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Trans-4-tert-Butylcyclohexanol suits: normal, dry, combination, oily, sensitive.
A soothing active for reactive skin.
The INCI name is Trans-4-tert-Butylcyclohexanol. It may also appear as: Транс-4-трет-бутилциклогексанол, 4-t-Butylcyclohexanol, 4-tButylcyclohexanol.
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