Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-47
A recombinant peptide. The maker links it to skin renewal; independent data are limited. Well tolerated.
Evidence by route
Topical application
A recombinant peptide. Well tolerated; independent data limited.
- CIR Cosmetic Ingredient Review safety assessment
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Combination, Oily, Sensitive
About this ingredient
This recombinant peptide from Nicotiana benthamiana (INCI Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-47) is a protein fragment made by biotechnology: the peptide gene is inserted into a tobacco plant, which then produces the molecule. In skincare it is positioned as an active for skin renewal and firmness. On efficacy we stay reserved. The manufacturer links the peptide to skin repair, but independent clinical data is still limited and the evidence base is modest. It reads more as a supporting ingredient in a formula than a standalone workhorse active. Do not expect visible rejuvenation from it. Used topically the peptide has no systemic relevance, so it can be used during pregnancy and breastfeeding without restriction. Tolerance is good. The irritation and allergy potential is low, which suits sensitive skin. Recombinant peptides come in purified form, and most people show no reaction.
Frequently asked questions
Is Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-47 safe during pregnancy?
Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-47 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-47 for?
Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-47 suits: normal, dry, combination, oily, sensitive.
What is Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-47 and what does it do in cosmetics?
A recombinant peptide.
What's the INCI name for Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-47?
The INCI name is Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-47.
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