A synthetic peptide. Makers link it to support for skin renewal; independent evidence is still limited. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A peptide active. Well tolerated; independent data limited.
Oleoyl Tetrapeptide-31 is a synthetic peptide bound to an oleic acid chain, which gives it affinity with the oil phase. Manufacturers link it to support for skin renewal, within the family of cosmetic peptides. On efficacy, the fair point is that independent evidence is still thin. The data comes mostly from the supplier rather than broad outside studies. It works as a support ingredient, not as an active with firm backing like a retinoid. It makes sense as an add-on within a routine, without expecting a result from it alone. Applied topically there is no meaningful systemic absorption, so it can be used during pregnancy and breastfeeding. Tolerance is good: low irritation and allergy potential, suitable for sensitive skin. Peptides of this class rarely cause a reaction and combine well with other common ingredients.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Oleoyl Tetrapeptide-31 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Oleoyl Tetrapeptide-31 suits: normal, dry, combination, oily, sensitive.
A synthetic peptide.
The INCI name is Oleoyl Tetrapeptide-31. It may also appear as: Олеоил тетрапептид-31.
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