A derivative of the amino acid isoleucine with a fatty acid. It holds moisture and supports skin smoothness. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A hydrating amino acid component. Safe.
Palmitoyl isoleucine (INCI: Palmitoyl Isoleucine) is the amino acid isoleucine joined to palmitic, a fatty acid. That pairing gives it a lipid character and affinity for the skin, so it acts as a conditioner: it helps retain water and keep a smooth, supple surface. As an active it plays a supporting role. It adds hydration and comfort, useful on dry skin, though specific evidence is modest and it is not a treatment for wrinkles or dark spots. The reasonable view is one more humectant-conditioner within the formula. Applied topically it has no systemic significance, so it can be used in pregnancy and breastfeeding. Tolerance is good. Irritation and allergy potential are low and it suits sensitive skin. At cosmetic concentrations reactions are rare.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Palmitoyl Isoleucine is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Palmitoyl Isoleucine suits: normal, dry, combination, oily, sensitive.
A derivative of the amino acid isoleucine with a fatty acid.
The INCI name is Palmitoyl Isoleucine. It may also appear as: Пальмитоил изолейцин.
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