Palmitoyl Isoleucine
A derivative of the amino acid isoleucine with a fatty acid. It holds moisture and supports skin smoothness. Well tolerated.
Evidence by route
Topical application
A hydrating amino acid component. Safe.
- CIR Cosmetic Ingredient Review safety assessment
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Combination, Oily, Sensitive
About this ingredient
Palmitoyl isoleucine (INCI: Palmitoyl Isoleucine) is the amino acid isoleucine joined to palmitic, a fatty acid. That pairing gives it a lipid character and affinity for the skin, so it acts as a conditioner: it helps retain water and keep a smooth, supple surface. As an active it plays a supporting role. It adds hydration and comfort, useful on dry skin, though specific evidence is modest and it is not a treatment for wrinkles or dark spots. The reasonable view is one more humectant-conditioner within the formula. Applied topically it has no systemic significance, so it can be used in pregnancy and breastfeeding. Tolerance is good. Irritation and allergy potential are low and it suits sensitive skin. At cosmetic concentrations reactions are rare.
Frequently asked questions
Is Palmitoyl Isoleucine safe during pregnancy?
Palmitoyl Isoleucine is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Palmitoyl Isoleucine for?
Palmitoyl Isoleucine suits: normal, dry, combination, oily, sensitive.
What is Palmitoyl Isoleucine and what does it do in cosmetics?
A derivative of the amino acid isoleucine with a fatty acid.
What's the INCI name for Palmitoyl Isoleucine?
The INCI name is Palmitoyl Isoleucine.
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